Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 19/20 | 0.76 |
| ▸ | UBA3 | Q8TBC4 | 19/20 | 0.76 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18526987 | 0.78 | NAE1 (0.63) | NAE1UBA3OPRK1KCNH2 | |
| SCHEMBL23456068 | 0.69 | NAE1 (0.57) | NAE1UBA3OPRK1KCNH2 | |
| SCHEMBL23487922 | 0.69 | NAE1 (0.57) | NAE1UBA3OPRK1KCNH2 | |
| SCHEMBL783611 | 0.67 | NAE1 (1.00) | NAE1UBA3 | |
| SCHEMBL15025759 | 0.66 | NAE1 (0.51) | NAE1UBA3 | |
| SCHEMBL783729 | 0.64 | NAE1 (0.88) | NAE1UBA3 | |
| SCHEMBL783582 | 0.64 | NAE1 (0.75) | NAE1UBA3 | |
| SCHEMBL23456099 | 0.63 | NAE1 (0.47) | NAE1UBA3 | |
| SCHEMBL30164347 | 0.63 | NAE1 (0.47) | NAE1UBA3 | |
| SCHEMBL3912788 | 0.62 | LMNA (0.44) | NAE1UBA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150525-B2 | Heteroaryl compounds useful as inhibitors of E1 activating enzymes | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-10-06 | — | — | US | disclosed |
| US-9150525-B2 | Heteroaryl compounds useful as inhibitors of E1 activating enzymes | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-10-06 | — | — | US | disclosed |