Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12493926 | 0.88 | MAPT (0.48) | HTTMAPTKDM4EGAATP53 | |
| SCHEMBL17145345 | 0.80 | MAPT (0.41) | HTTMAPTKDM4EGAATP53 | |
| SCHEMBL17145858 | 0.80 | MAPT (0.41) | HTTMAPTKDM4EGAATP53 | |
| SCHEMBL12524657 | 0.76 | KDM4E (0.44) | HTTMAPTKDM4EGAATP53 | |
| SCHEMBL29488 | 0.76 | LMNA (0.50) | HTTMAPTKDM4EGAAHSD17B10 | |
| SCHEMBL12494851 | 0.75 | LMNA (0.39) | HTTMAPTKDM4EGAATP53 | |
| SCHEMBL17145346 | 0.75 | KLKB1 (0.46) | HTTMAPTKDM4EGAATP53 | |
| SCHEMBL18123828 | 0.75 | LMNA (0.39) | HTTMAPTKDM4EGAATP53 | |
| SCHEMBL12525445 | 0.74 | PDE4A (0.38) | HTTMAPTKDM4EGAATP53 | |
| SCHEMBL18123713 | 0.74 | PDE4A (0.38) | HTTMAPTKDM4EGAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150530-B2 | Esters of 4, 9-dihydroxy-naphtho [2, 3-b] furans for disease therapies | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2015-10-06 | — | — | US | disclosed |
| US-9150530-B2 | Esters of 4, 9-dihydroxy-naphtho [2, 3-b] furans for disease therapies | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2015-10-06 | — | — | US | disclosed |