Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 7/20 | 1.00 |
| ▸ | UBA3 | Q8TBC4 | 7/20 | 1.00 |
| ▸ | UBA1 | P22314 | 12/20 | 0.47 |
| ▸ | UBE2E1 | P51965 | 12/20 | 0.47 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.45 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL783253 | 1.00 | NAE1 (1.00) | NAE1UBA3UBA1UBE2E1SAE1 | |
| SCHEMBL783123 | 0.83 | NAE1 (1.00) | NAE1UBA3UBA1UBE2E1SAE1 | |
| SCHEMBL783835 | 0.82 | NAE1 (0.70) | NAE1UBA3UBA1UBE2E1SAE1 | |
| SCHEMBL805391 | 0.81 | NAE1 (0.68) | NAE1UBA3 | |
| SCHEMBL782980 | 0.76 | NAE1 (0.68) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL17145363 | 0.76 | NAE1 (0.68) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL2349048 | 0.75 | NAE1 (0.61) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL14719972 | 0.74 | NAE1 (0.65) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL782474 | 0.74 | NAE1 (0.65) | NAE1UBA3UBA1UBE2E1 | |
| SCHEMBL18540598 | 0.74 | NAE1 (0.58) | NAE1UBA3UBA1UBE2E1SAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150525-B2 | Heteroaryl compounds useful as inhibitors of E1 activating enzymes | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-10-06 | — | — | US | disclosed |