Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | INPPL1 | O15357 | 2/20 | 0.38 |
| ▸ | INPP5A | Q14642 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | STAT3 | P40763 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17145858 | 0.92 | MAPT (0.41) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL17145347 | 0.89 | PDE4A (0.35) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL29488 | 0.80 | LMNA (0.50) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL12493926 | 0.78 | MAPT (0.48) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL20089233 | 0.75 | LMNA (0.37) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL17145346 | 0.74 | KLKB1 (0.46) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL12494851 | 0.74 | LMNA (0.39) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL18123828 | 0.74 | LMNA (0.39) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL12525445 | 0.73 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL18123713 | 0.73 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079864-A1 | TREATMENT OF CANCERS RELATED TO CHRONICALLY ACTIVE RAS | HANGZHOU YIER BIOTECH CO., LTD. (CN) | 2017-05-18 | — | — | WO | disclosed |
| US-9150530-B2 | Esters of 4, 9-dihydroxy-naphtho [2, 3-b] furans for disease therapies | ZHOUSHAN HAIZHONGZHOU XINSHENG PHARMACEUTICALS CO., LTD. (CN) | 2015-10-06 | — | — | US | disclosed |