Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CKS1B | P61024 | 2/20 | 0.39 |
| ▸ | SKP1 | P63208 | 2/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | F13A1 | P00488 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | TGM1 | P22735 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30512278 | 0.91 | MAPT (0.52) | GPR119MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL14925978 | 0.91 | MAPT (0.52) | GPR119MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL14933994 | 0.88 | GPR119 (0.49) | GPR119MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL14930420 | 0.84 | GPR119 (0.51) | GPR119MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL29741868 | 0.84 | GPR119 (0.50) | GPR119MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL17525877 | 0.82 | MAPT (0.59) | GPR119MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL16357010 | 0.82 | GPR119 (0.48) | GPR119MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL38661127 | 0.77 | GPR119 (0.49) | GPR119MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL12740840 | 0.75 | GPR119 (0.65) | GPR119MAPTCKS1BSKP1SKP2 | |
| SCHEMBL14915852 | 0.74 | POLB (0.48) | MAPTALDH1A1LMNASMN1; SMN2TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773638-B1 | HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS AS INHIBITORS OF BTK ACTIVITY | HOFFMANN LA ROCHE (CH) | 2015-10-07 | — | — | EP | disclosed |