Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3194630 | 0.82 | MAPT (0.61) | GPR119MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL25827214 | 0.82 | GPR119 (0.56) | NR1H2GPR119MAPTALDH1A1LMNA | |
| SCHEMBL55667 | 0.77 | MAPT (0.67) | NR1H2GPR119MAPTALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL7371653 | 0.76 | MAPT (0.65) | NR1H2GPR119MAPTALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL4934215 | 0.76 | MAPT (0.65) | NR1H2GPR119MAPTALDH1A1LMNA | |
| SCHEMBL24320204 | 0.73 | GPR119 (0.48) | GPR119MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL3968708 | 0.73 | USP2 (0.49) | NR1H2GPR119MAPTALDH1A1LMNA | |
| SCHEMBL21946732 | 0.72 | MAPK1 (0.54) | NR1H2GPR119MAPTALDH1A1LMNA | |
| SCHEMBL10036433 | 0.72 | GPR119 (0.79) | GPR119MAPTALDH1A1LMNA | |
| SCHEMBL5231173 | 0.71 | GPR119 (0.70) | GPR119MAPTALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015154023-A1 | SUBSTITUTED SPIROCYDIC INHIBITORS OF AUTOTAXIN | X-RX DISCOVERY, INC. (US) | 2015-10-08 | — | — | WO | disclosed |