Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 15/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.49 |
| ▸ | CCNK | O75909 | 9/20 | 0.49 |
| ▸ | CDK9 | P50750 | 9/20 | 0.49 |
| ▸ | CDK12 | Q9NYV4 | 9/20 | 0.49 |
| ▸ | CCNH | P51946 | 7/20 | 0.49 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.44 |
| ▸ | CDK2 | P24941 | 6/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17150734 | 0.86 | CDK7 (0.69) | CDK7CCNT1CCNKCDK9CDK12 | |
| SCHEMBL16665176 | 0.82 | CDK7 (0.75) | CDK7CCNT1CCNKCDK9CDK12 | |
| SCHEMBL16665173 | 0.82 | CDK7 (0.75) | CDK7CCNT1CCNKCDK9CDK12 | |
| Hydrochloric Acid SCHEMBL18047324 | 0.82 | CDK7 (0.74) | CDK7CCNT1CCNKCDK9CDK12 | |
| SCHEMBL19040153 | 0.79 | CDK7 (0.49) | CDK7CCNT1CCNKCDK9CDK12 | |
| SCHEMBL19024461 | 0.79 | CDK7 (0.70) | CDK7CCNT1CCNKCDK9CDK12 | |
| SCHEMBL17150710 | 0.79 | HTR6 (0.46) | CDK7CCNT1CCNKCDK9CDK12 | |
| SCHEMBL17150546 | 0.77 | CDK7 (0.84) | CDK7CCNT1CCNKCDK9CDK12 | |
| SCHEMBL18047328 | 0.77 | CDK7 (0.65) | CDK7CCNT1CCNKCDK9CDK12 | |
| SCHEMBL17150714 | 0.75 | CCNK (0.53) | CDK7CCNT1CCNKCDK9CDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015154039-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2015-10-08 | — | — | WO | disclosed |