Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 18/20 | 0.57 |
| ▸ | CCNT1 | O60563 | 13/20 | 0.57 |
| ▸ | CDK9 | P50750 | 13/20 | 0.57 |
| ▸ | CCNH | P51946 | 13/20 | 0.57 |
| ▸ | CCNK | O75909 | 10/20 | 0.57 |
| ▸ | CDK12 | Q9NYV4 | 10/20 | 0.57 |
| ▸ | MNAT1 | P51948 | 9/20 | 0.57 |
| ▸ | CDK13 | Q14004 | 7/20 | 0.56 |
| ▸ | CDK2 | P24941 | 9/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.55 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.52 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19024596 | 0.86 | CDK7 (0.72) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL17151941 | 0.86 | CDK7 (0.68) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL21026995 | 0.86 | CDK7 (0.43) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL17150705 | 0.84 | CDK7 (0.81) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL20764205 | 0.84 | CDK7 (0.61) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL19024571 | 0.83 | CDK7 (0.41) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL17151962 | 0.83 | CDK7 (0.40) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL17150423 | 0.80 | CDK7 (0.59) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL19024498 | 0.79 | CDK7 (0.60) | CDK7CCNT1CDK9CCNHCCNK | |
| SCHEMBL20416415 | 0.78 | CDK7 (0.72) | CDK7CCNT1CDK9CCNHCCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015154038-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2015-10-08 | — | — | WO | disclosed |