Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 18/20 | 0.43 |
| ▸ | CCNH | P51946 | 16/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 14/20 | 0.43 |
| ▸ | CDK9 | P50750 | 14/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 12/20 | 0.43 |
| ▸ | CCNK | O75909 | 9/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 9/20 | 0.43 |
| ▸ | CDK13 | Q14004 | 7/20 | 0.42 |
| ▸ | CDK2 | P24941 | 7/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19024571 | 0.90 | CDK7 (0.41) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL17151962 | 0.89 | CDK7 (0.40) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL17151963 | 0.86 | CDK7 (0.57) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL20994619 | 0.80 | CDK7 (0.44) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL17150470 | 0.78 | CDK7 (0.45) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL19580260 | 0.78 | CDK7 (0.53) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL19580261 | 0.78 | CDK7 (0.53) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL19040150 | 0.78 | CDK7 (0.60) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL17150634 | 0.77 | CCNT1 (0.38) | CDK7CCNHCCNT1CDK9MNAT1 | |
| SCHEMBL17688369 | 0.76 | CDK7 (0.49) | CDK7CCNHCCNT1CDK9MNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489232-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2019-05-29 | — | — | EP | disclosed |