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SCHEMBL17152

SCHEMBL17152

CC(C)N(C[C@@]1(c2ccc(C(C)(O)C(F)(F)F)cc2)CN(S(=O)(=O)C2=CC=CCC2=S)CCN1)S(=O)(=O)c1cccnc1

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ HSD11B1 P28845 11/20 0.37
▸ RORC P51449 1/20 0.32
▸ CYP3A4 P08684 1/20 0.32
▸ KCNH2 Q12809 1/20 0.32
▸ NR1H2 P55055 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18291 0.93 HSD11B1 (0.39) HSD11B1RORCCYP3A4KCNH2NR1H2
SCHEMBL17936 0.88 HSD11B1 (0.31) HSD11B1CYP3A4KCNH2
SCHEMBL16466 0.87 HSD11B1 (0.39) HSD11B1RORCCYP3A4KCNH2
SCHEMBL16748 0.85 HSD11B1 (0.35) HSD11B1
SCHEMBL18402 0.83 HSD11B1 (0.32) HSD11B1RORCCYP3A4KCNH2
SCHEMBL18340 0.82 HSD11B1 (0.32) HSD11B1RORCCYP3A4KCNH2
SCHEMBL17585 0.82 HSD11B1 (0.31) HSD11B1
SCHEMBL16877 0.82 HSD11B1 (0.31) HSD11B1
SCHEMBL16862 0.82 HSD11B1 (0.31) HSD11B1
SCHEMBL16811 0.80 HSD11B1 (0.31) HSD11B1RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2609081-A1 SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES Amgen Inc. (US) 2013-07-03 — — EP claimed
WO-2012027261-A1 SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES AMGEN INC. (US) 2012-03-01 — — WO claimed