Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17152622 | 1.00 | DPP4 (0.39) | DPP4DPP8POLBL3MBTL1CNR2 | |
| SCHEMBL17152504 | 0.79 | ENPP2 (0.36) | POLBENPP2RAB9A | |
| SCHEMBL17152317 | 0.76 | ENPP2 (0.34) | ENPP2 | |
| SCHEMBL2849479 | 0.76 | POLB (0.43) | DPP4DPP8POLBL3MBTL1CNR2 | |
| SCHEMBL5079416 | 0.76 | POLB (0.43) | DPP4DPP8POLBL3MBTL1CNR2 | |
| SCHEMBL2843566 | 0.76 | POLB (0.43) | DPP4DPP8POLBL3MBTL1CNR2 | |
| SCHEMBL25637926 | 0.75 | BTK (0.41) | DPP4DPP8POLBL3MBTL1CNR2 | |
| SCHEMBL9309085 | 0.75 | BTK (0.41) | DPP4DPP8POLBL3MBTL1CNR2 | |
| SCHEMBL17152254 | 0.74 | DPP4 (0.38) | DPP4POLBENPP2RAB9A | |
| SCHEMBL24735808 | 0.73 | DPP4 (0.43) | DPP4DPP8POLBL3MBTL1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897939-B1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES FOR TREATING METABOLIC OR CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2017-02-01 | — | — | EP | disclosed |
| US-9156796-B2 | Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators | SANOFI (FR) | 2015-10-13 | — | — | US | disclosed |