Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18406816 | 0.86 | OPRL1 (0.39) | OPRL1OPRM1OPRD1PDE4APDE4B | |
| SCHEMBL18411395 | 0.83 | OPRL1 (0.37) | OPRL1OPRM1OPRD1PDE4APDE4B | |
| SCHEMBL18406815 | 0.82 | SCD (0.39) | OPRL1OPRM1OPRD1PDE4APDE4B | |
| SCHEMBL18411501 | 0.73 | EPHX2 (0.50) | OPRM1OPRD1CCR5EPHX2HRH1 | |
| SCHEMBL17155368 | 0.69 | OPRL1 (0.36) | OPRL1OPRM1OPRD1CCR5 | |
| SCHEMBL17155353 | 0.69 | SLC6A2 (0.48) | OPRM1CCR5KMT2A | |
| SCHEMBL17155077 | 0.67 | MAPK1 (0.42) | OPRL1OPRM1CCR5KMT2ASMN1; SMN2 | |
| SCHEMBL17155018 | 0.66 | KMT2A (0.37) | OPRL1OPRM1OPRD1CCR5KMT2A | |
| SCHEMBL23163989 | 0.66 | ACACB (0.48) | KMT2AEPHX2 | |
| SCHEMBL29731444 | 0.66 | ACACB (0.48) | KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015150557-A1 | MACROCYLIC PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2015-10-08 | — | — | WO | disclosed |