Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 5/20 | 0.60 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.58 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ABAT | P80404 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.33 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.32 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156135 | 0.89 | DHODH (0.74) | DHODHTMEM97ADRB3ADRA1DSLC6A4 | |
| SCHEMBL17156388 | 0.88 | DHODH (0.46) | DHODHTMEM97ADRB3ADRA1DSLC6A4 | |
| SCHEMBL17156209 | 0.86 | DHODH (0.81) | DHODHTMEM97ADRB3ADRA1DSLC6A4 | |
| SCHEMBL17156379 | 0.80 | DHODH (0.44) | DHODHTMEM97NPC1RAB9ASMO | |
| SCHEMBL17156340 | 0.80 | DHODH (0.62) | DHODHTMEM97ADRB3ADRA1DSLC6A4 | |
| SCHEMBL17156091 | 0.78 | DHODH (0.61) | DHODHTMEM97ADRB3ADRA1DSLC6A4 | |
| SCHEMBL17156206 | 0.78 | DHODH (0.57) | DHODHTMEM97ADRB3ADRA1DSLC6A4 | |
| SCHEMBL17156258 | 0.77 | DHODH (0.56) | DHODHTMEM97ADRB3ADRA1DSLC6A4 | |
| SCHEMBL17156185 | 0.76 | DHODH (0.58) | DHODHTMEM97ADRB3ADRA1DSLC6A4 | |
| SCHEMBL3261575 | 0.76 | NPC1 (0.52) | DHODHNPC1RAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2929883-A1 | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors | INSTITUT PASTEUR (FR) | 2015-10-14 | — | — | EP | disclosed |