Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ABAT | P80404 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.33 |
| ▸ | ACACB | O00763 | 5/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156258 | 0.89 | DHODH (0.56) | DHODHSLC6A4TMEM97ADRB3ADRA1D | |
| SCHEMBL17156110 | 0.88 | DHODH (0.56) | DHODHSLC6A4TMEM97ADRB3ADRA1D | |
| SCHEMBL17156135 | 0.86 | DHODH (0.74) | DHODHSLC6A4TMEM97ADRB3ADRA1D | |
| SCHEMBL17156336 | 0.78 | DHODH (0.52) | DHODHSLC6A4TMEM97ADRB3ADRA1D | |
| SCHEMBL17156198 | 0.78 | DHODH (0.60) | DHODHSLC6A4TMEM97ADRB3ADRA1D | |
| SCHEMBL17156340 | 0.78 | DHODH (0.62) | DHODHSLC6A4TMEM97ADRB3ADRA1D | |
| SCHEMBL17156091 | 0.76 | DHODH (0.61) | DHODHSLC6A4TMEM97ADRB3ADRA1D | |
| SCHEMBL17156185 | 0.74 | DHODH (0.58) | DHODHSLC6A4TMEM97ADRB3ADRA1D | |
| SCHEMBL17156326 | 0.73 | DHODH (0.57) | DHODHSLC6A4TMEM97ADRB3ADRA1D | |
| SCHEMBL17156207 | 0.73 | DHODH (1.00) | DHODHSLC6A4TMEM97ADRB3ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2929883-A1 | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors | INSTITUT PASTEUR (FR) | 2015-10-14 | — | — | EP | disclosed |