Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 13/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 13/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 13/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 13/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 13/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 13/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17158442 | 0.90 | S1PR2 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17158554 | 0.90 | PTGS1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17158485 | 0.88 | TACR1 (0.31) | — | |
| SCHEMBL17158380 | 0.88 | MEN1 (0.38) | GAAMAPTNPSR1CYP3A4CYP2D6 | |
| SCHEMBL17158532 | 0.88 | MEN1 (0.38) | GAAMAPTNPSR1CYP3A4CYP2D6 | |
| SCHEMBL17158379 | 0.88 | MEN1 (0.38) | GAAMAPTNPSR1CYP3A4CYP2D6 | |
| SCHEMBL17177013 | 0.88 | MEN1 (0.38) | GAAMAPTNPSR1CYP3A4CYP2D6 | |
| SCHEMBL17158447 | 0.88 | MEN1 (0.38) | GAAMAPTNPSR1CYP3A4CYP2D6 | |
| SCHEMBL17158424 | 0.81 | HTR1A (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17158476 | 0.81 | PSEN1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3470406-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2019-04-17 | — | — | EP | claimed |
| US-9896440-B2 | Aryl substituted heterocyclyl sulfones | Grünenthal GmbH (DE) | 2018-02-20 | — | — | US | claimed |
| US-20150291573-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-15 | — | — | US | claimed |
| CN-106458955-B | Aryl substituted heterocyclyl sulfones | 格吕伦塔尔有限公司 | 2019-07-19 | — | — | CN | disclosed |
| EP-3470406-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2019-04-17 | — | — | EP | disclosed |
| US-9896440-B2 | Aryl substituted heterocyclyl sulfones | Grünenthal GmbH (DE) | 2018-02-20 | — | — | US | disclosed |
| US-9896440-B2 | Aryl substituted heterocyclyl sulfones | Grünenthal GmbH (DE) | 2018-02-20 | — | — | US | disclosed |
| EP-3131884-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2017-02-22 | — | — | EP | disclosed |
| CN-106458955-A | Aryl substituted heterocyclyl sulfones | 格吕伦塔尔有限公司 | 2017-02-22 | — | — | CN | disclosed |
| WO-2015158426-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-22 | — | — | WO | disclosed |
| WO-2015158426-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-22 | — | — | WO | disclosed |
| US-20150291573-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-15 | — | — | US | disclosed |
| US-20150291573-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-15 | — | — | US | disclosed |
| US-20150291573-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291573-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | TRPV1, CACNA1B, CACNA1C | PSEN1 721/4885PSEN2 736/4885APH1B 1071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.