SCHEMBL17159381

SCHEMBL17159381

O=C(NC1CCCC1)c1csc([C@@H]2C[C@H]2NC2CCOCC2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAOA P21397 4/20 1.00
KDM1A O60341 16/20 0.96
MAOB P27338 2/20 0.79
RCOR1 Q9UKL0 2/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17158667 1.00 MAOA (1.00) MAOAKDM1AMAOBRCOR1
SCHEMBL17159214 1.00 MAOA (1.00) MAOAKDM1AMAOBRCOR1
Hydrochloric Acid SCHEMBL17158970 0.99 MAOA (0.98) MAOAKDM1AMAOBRCOR1
Hydrochloric Acid SCHEMBL17158972 0.99 MAOA (0.98) MAOAKDM1AMAOBRCOR1
SCHEMBL17159140 0.98 KDM1A (1.00) MAOAKDM1AMAOBRCOR1
SCHEMBL17159382 0.98 KDM1A (1.00) MAOAKDM1AMAOBRCOR1
SCHEMBL17159252 0.98 KDM1A (1.00) MAOAKDM1AMAOBRCOR1
Hydrochloric Acid SCHEMBL23496199 0.97 KDM1A (0.98) MAOAKDM1AMAOBRCOR1
Hydrochloric Acid SCHEMBL17164821 0.97 KDM1A (0.98) MAOAKDM1AMAOBRCOR1
Hydrochloric Acid SCHEMBL17158947 0.97 KDM1A (0.98) MAOAKDM1AMAOBRCOR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240317733-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2024-09-26 US disclosed
US-20210179603-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2021-06-17 US disclosed
US-10968213-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2021-04-06 US disclosed
US-20190315735-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2019-10-17 US disclosed
US-10414761-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-09-17 US disclosed
US-10053456-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-08-21 US disclosed
US-20180162853-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2018-06-14 US disclosed
US-9920047-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-03-20 US disclosed
US-9718814-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-08-01 US disclosed
US-9714241-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-07-25 US disclosed
US-20170029417-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-02-02 US disclosed
US-20170001994-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2017-01-05 US disclosed
US-9487511-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-11-08 US disclosed
US-20160311808-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2016-10-27 US disclosed
US-20160311814-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2016-10-27 US disclosed
US-20150291577-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-10-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190315735-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A MAOA 493/4885KDM1A 1/4885MAOB 495/4885
US-20160311808-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A MAOA 493/4885KDM1A 1/4885MAOB 495/4885
US-20180162853-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A MAOA 493/4885KDM1A 1/4885MAOB 495/4885
US-10053456-B2 Cyclopropanamine compound and use thereof KDM1A, KDM1B, KDM2A MAOA 493/4885KDM1A 1/4885MAOB 495/4885
US-20210179603-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A MAOA 493/4885KDM1A 1/4885MAOB 495/4885
US-20240317733-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A MAOA 499/4885KDM1A 1/4885MAOB 525/4885
US-10968213-B2 Cyclopropanamine compound and use thereof KDM1A, KDM1B, KDM2A MAOA 493/4885KDM1A 1/4885MAOB 495/4885
US-20170001994-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A MAOA 493/4885KDM1A 1/4885MAOB 495/4885
US-10414761-B2 Cyclopropanamine compound and use thereof KDM1A, KDM1B, KDM2A MAOA 493/4885KDM1A 1/4885MAOB 495/4885
US-20150291577-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A MAOA 493/4885KDM1A 1/4885MAOB 495/4885
US-20170029417-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A MAOA 493/4885KDM1A 1/4885MAOB 495/4885
US-20160311814-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A MAOA 493/4885KDM1A 1/4885MAOB 495/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.