SCHEMBL17161981

SCHEMBL17161981

Cc1c(COc2cc(OCc3cncc(C#N)c3)c(CNC(CO)C(=O)O)cc2Cl)cccc1-c1ccc2c(c1)OCCO2

nearest known ligand 0.89

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CD274 Q9NZQ7 20/20 0.89
PDCD1 Q15116 19/20 0.89

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17161979 1.00 CD274 (0.89) CD274PDCD1
SCHEMBL17161471 0.94 PDCD1 (0.84) CD274PDCD1
SCHEMBL17161474 0.94 PDCD1 (0.84) CD274PDCD1
SCHEMBL17161634 0.94 PDCD1 (0.84) CD274PDCD1
SCHEMBL17161834 0.94 CD274 (1.00) CD274PDCD1
SCHEMBL17161830 0.94 CD274 (1.00) CD274PDCD1
SCHEMBL17161976 0.93 PDCD1 (0.82) CD274PDCD1
SCHEMBL17161599 0.93 PDCD1 (0.82) CD274PDCD1
SCHEMBL17161722 0.93 PDCD1 (0.82) CD274PDCD1
SCHEMBL17161602 0.93 PDCD1 (0.82) CD274PDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3131876-B1 COMPOUNDS USEFUL AS IMMUNOMODULATORS BRISTOL MYERS SQUIBB CO (US) 2018-11-07 EP claimed
US-9850225-B2 Compounds useful as immunomodulators BRISTOL-MYERS SQUIBB COMPANY (US) 2017-12-26 US claimed
EP-3131876-A2 COMPOUNDS USEFUL AS IMMUNOMODULATORS Bristol-Myers Squibb Company (US) 2017-02-22 EP claimed
WO-2015160641-A2 COMPOUNDS USEFUL AS IMMUNOMODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2015-10-22 WO claimed
US-20150291549-A1 Compounds Useful as Immunomodulators BRISTOL-MYERS SQUIBB COMPANY 2015-10-15 US claimed
EP-3131876-B1 COMPOUNDS USEFUL AS IMMUNOMODULATORS BRISTOL MYERS SQUIBB CO (US) 2018-11-07 EP disclosed
US-9850225-B2 Compounds useful as immunomodulators BRISTOL-MYERS SQUIBB COMPANY (US) 2017-12-26 US disclosed
EP-3131876-A2 COMPOUNDS USEFUL AS IMMUNOMODULATORS Bristol-Myers Squibb Company (US) 2017-02-22 EP disclosed
WO-2015160641-A2 COMPOUNDS USEFUL AS IMMUNOMODULATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2015-10-22 WO disclosed
US-20150291549-A1 Compounds Useful as Immunomodulators BRISTOL-MYERS SQUIBB COMPANY 2015-10-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150291549-A1 Compounds Useful as Immunomodulators CD74, HLA-DRB1, CD47 CD274 52/4885PDCD1 161/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.