Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.60 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL799251 | 0.92 | PIK3CD (0.62) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48660 | 0.76 | PIK3CG (1.00) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48835 | 0.75 | PIK3CD (0.81) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL27658350 | 0.75 | PIK3CD (0.70) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1784923 | 0.75 | PIK3CD (0.70) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL12363422 | 0.74 | PIK3CD (0.80) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL799253 | 0.74 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1785642 | 0.74 | PIK3CG (0.63) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1784085 | 0.74 | PIK3CG (0.68) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1784080 | 0.74 | PIK3CG (0.68) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426135-A1 | UREA DERIVATIVE HAVING PI3K INHIBITORY ACTIVITY | Shionogi&Co., Ltd. (JP) | 2012-03-07 | — | — | EP | disclosed |