Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 12/20 | 0.79 |
| ▸ | MAPT | P10636 | 4/20 | 0.78 |
| ▸ | EBP | Q15125 | 4/20 | 0.78 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.78 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.78 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.78 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.78 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.78 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.78 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.78 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.78 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.78 |
| ▸ | DRD3 | P35462 | 3/20 | 0.78 |
| ▸ | HTR6 | P50406 | 3/20 | 0.78 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.78 |
| ▸ | MEN1 | O00255 | 3/20 | 0.78 |
| ▸ | PGR | P06401 | 3/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17164687 | 1.00 | ESR1 (0.79) | ESR1MAPTEBPSIGMAR1KMT2A | |
| SCHEMBL10349624 | 0.94 | PDE1A (0.80) | ESR1MAPTEBPSIGMAR1KMT2A | |
| SCHEMBL10349626 | 0.94 | PDE1A (0.80) | ESR1MAPTEBPSIGMAR1KMT2A | |
| SCHEMBL10349622 | 0.94 | PDE1A (0.80) | ESR1MAPTEBPSIGMAR1KMT2A | |
| SCHEMBL1152821 | 0.91 | ESR1 (0.80) | ESR1MAPTEBPSIGMAR1KMT2A | |
| SCHEMBL1152819 | 0.91 | ESR1 (0.80) | ESR1MAPTEBPSIGMAR1KMT2A | |
| SCHEMBL5079405 | 0.91 | ESR1 (0.80) | ESR1MAPTEBPSIGMAR1KMT2A | |
| SCHEMBL9451189 | 0.89 | ESR1 (0.72) | ESR1MAPTEBPSIGMAR1KMT2A | |
| SCHEMBL9451187 | 0.89 | ESR1 (0.72) | ESR1MAPTEBPSIGMAR1KMT2A | |
| SCHEMBL14044785 | 0.89 | ESR1 (0.71) | ESR1MAPTEBPSIGMAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12202897-B2 | Drug regulated transgene expression | SEATTLE CHILDREN'S HOSPITAL (US) | 2025-01-21 | — | — | US | disclosed |
| US-20240226160-A9 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2024-07-11 | — | — | US | disclosed |
| CN-110291200-B | Agent ligand induction of transgene expression in mammalian cells | 西雅图儿童医院（DBA西雅图儿童研究所） | 2024-05-14 | — | — | CN | disclosed |
| US-20240131072-A1 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) | 2024-04-25 | — | — | US | disclosed |
| EP-4341283-A2 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A TRANSCRIPTION FACTOR AND A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (US) | 2024-03-27 | — | — | EP | disclosed |
| EP-4291571-A2 | ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN | Seattle Children's Hospital d/b/a Seattle Children's Research Institute (US) | 2023-12-20 | — | — | EP | disclosed |
| CN-117177989-A | Activity-inducible fusion proteins with heat shock protein 90 binding domain | 西雅图儿童医院以西雅图儿童研究机构名义经营 | 2023-12-05 | — | — | CN | disclosed |
| EP-3551197-B1 | CHIMERIC TRANSCRIPTION FACTOR VARIANTS WITH AUGMENTED SENSITIVITY TO DRUG LIGAND INDUCTION OF TRANSGENE EXPRESSION IN MAMMALIAN CELLS | SEATTLE CHILDRENS HOSPITAL DBA SEATTLE CHILDRENS RES INST (US) | 2023-11-22 | — | — | EP | disclosed |
| WO-2023187031-A1 | A SYSTEM FOR DRUG-INDUCIBLE EXPRESSION OF A POLYNUCLEOTIDE | Miltenyi Biotec B.V. & Co. KG (DE) | 2023-10-05 | — | — | WO | disclosed |
| US-20230242936-A1 | DUAL PROMOTER SYSTEMS | SEATTLE CHILDRENS HOSPITAL DBA SEATTLE CHILDRENS RES INST (US) | 2023-08-03 | — | — | US | disclosed |
| US-20190016776-A1 | TUMOR-SPECIFIC IFNA SECRETION BY CAR T-CELLS TO REPROGRAM THE SOLID TUMOR MICROENVIRONMENT | Seattle Children's Hospital (dba Seattle Children's Research Institute) | 2019-01-17 | — | — | US | disclosed |
| EP-3402509-A1 | TUMOR-SPECIFIC IFNA SECRETION BY CAR T-CELLS TO REPROGRAM THE SOLID TUMOR MICROENVIRONMENT | Seattle Children's Hospital (DBA Seattle Children's Research Institute) (US) | 2018-11-21 | — | — | EP | disclosed |
| CN-108174604-A | For the bispecific CAR T cells of solid tumor targeting | 西雅图儿童医院（DBA西雅图儿童研究所） | 2018-06-15 | — | — | CN | disclosed |
| EP-3331920-A1 | BISPECIFIC CAR T-CELLS FOR SOLID TUMOR TARGETING | Seattle Children's Hospital, dba Seattle Children's Research Institute (US) | 2018-06-13 | — | — | EP | disclosed |
| WO-2017123548-A1 | TUMOR-SPECIFIC IFNA SECRETION BY CAR T-CELLS TO REPROGRAM THE SOLID TUMOR MICROENVIRONMENT | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2017-07-20 | — | — | WO | disclosed |
| US-20170152297-A1 | DRUG REGULATED TRANSGENE EXPRESSION | Seattle Children's Hospital (dba Seattle Children's Research Institute) | 2017-06-01 | — | — | US | disclosed |
| CN-106573969-A | Drug-related transgene expression | 西雅图儿童医院（DBA西雅图儿童研究所） | 2017-04-19 | — | — | CN | disclosed |
| WO-2017027291-A1 | BISPECIFIC CAR T-CELLS FOR SOLID TUMOR TARGETING | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2017-02-16 | — | — | WO | disclosed |
| EP-3129399-A1 | DRUG RELATED TRANSGENE EXPRESSION | Seattle Children's Hospital, dba Seattle Children's Research Institute (US) | 2017-02-15 | — | — | EP | disclosed |
| WO-2015157432-A1 | DRUG RELATED TRANSGENE EXPRESSION | Seattle Children's Hospital (dba Seattle Children's Research Institute) (US) | 2015-10-15 | — | — | WO | disclosed |