Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 13/20 | 0.72 |
| ▸ | EBP | Q15125 | 6/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.72 |
| ▸ | HTR6 | P50406 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 4/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.72 |
| ▸ | DRD3 | P35462 | 3/20 | 0.72 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.72 |
| ▸ | PGR | P06401 | 3/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9451187 | 1.00 | ESR1 (0.72) | ESR1EBPKMT2AMAPTSIGMAR1 | |
| SCHEMBL906173 | 0.90 | HTR6 (0.77) | ESR1EBPKMT2AMAPTSIGMAR1 | |
| SCHEMBL906174 | 0.90 | HTR6 (0.77) | ESR1EBPKMT2AMAPTSIGMAR1 | |
| SCHEMBL17164687 | 0.89 | ESR1 (0.79) | ESR1EBPKMT2AMAPTSIGMAR1 | |
| SCHEMBL17164682 | 0.89 | ESR1 (0.79) | ESR1EBPKMT2AMAPTSIGMAR1 | |
| SCHEMBL8140749 | 0.89 | ESR1 (0.74) | ESR1EBPKMT2AMAPTSIGMAR1 | |
| SCHEMBL14044785 | 0.87 | ESR1 (0.71) | ESR1EBPKMT2AMAPTSIGMAR1 | |
| SCHEMBL7801089 | 0.86 | ESR1 (0.67) | ESR1EBPKMT2AMAPTSIGMAR1 | |
| Zuclomiphene SCHEMBL34894 | 0.84 | ESR1 (1.00) | ESR1EBPKMT2AMAPTSIGMAR1 | |
| Enclomiphene SCHEMBL20594021 | 0.84 | ESR1 (1.00) | ESR1EBPKMT2AMAPTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0547179-A4 | TRIARYLETHYLENE CARBOXYLIC ACIDS WITH ESTROGENIC ACTIVITY | — | 1993-08-04 | — | — | EP | disclosed |
| EP-0547179-A1 | TRIARYLETHYLENE CARBOXYLIC ACIDS WITH ESTROGENIC ACTIVITY | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1993-06-23 | — | — | EP | disclosed |
| US-5189212-A | Used in estrogen replacement therapy like menopause, osteoporosis therapy, prevention of excessive hair growth of body and infertility | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1993-02-23 | — | — | US | disclosed |
| WO-1992004310-A1 | TRIARYLETHYLENE CARBOXYLIC ACIDS WITH ESTROGENIC ACTIVITY | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1992-03-19 | — | — | WO | disclosed |