Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
| ▸ | TACR3 | P29371 | 11/20 | 0.44 |
| ▸ | TACR2 | P21452 | 5/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1717750 | 0.92 | HTR7 (0.43) | HTR7TACR3TACR2OPRM1 | |
| SCHEMBL1718058 | 0.89 | TACR3 (0.47) | HTR7TACR3TACR2OPRM1 | |
| SCHEMBL1717610 | 0.89 | HTR7 (0.49) | HTR7TACR3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL1718018 | 0.89 | TACR3 (0.43) | HTR7TACR3TACR2OPRM1KDM4E | |
| SCHEMBL1718231 | 0.88 | TACR3 (0.49) | TACR3TACR2OPRM1KDM4EALDH1A1 | |
| SCHEMBL1717288 | 0.88 | TACR3 (0.47) | HTR7TACR3TACR2OPRM1 | |
| SCHEMBL1718782 | 0.87 | TACR3 (0.50) | TACR3TACR2OPRM1 | |
| SCHEMBL1719079 | 0.87 | TACR3 (0.56) | TACR3TACR2OPRM1MEN1KMT2A | |
| SCHEMBL1717859 | 0.87 | TACR3 (0.48) | TACR3TACR2OPRM1KDM4EALDH1A1 | |
| SCHEMBL1717555 | 0.87 | TACR3 (0.48) | TACR3TACR2OPRM1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150534-B1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | LUNDBECK & CO AS H (DK) | 2012-01-11 | — | — | EP | claimed |
| EP-2150534-B1 | ISOQUINOLINONE DERIVATIVES AS NK3 ANTAGONISTS | LUNDBECK & CO AS H (DK) | 2012-01-11 | — | — | EP | disclosed |