Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.71 |
| ▸ | ROCK1 | Q13464 | 13/20 | 0.65 |
| ▸ | PLK4 | O00444 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | PRKCG | P05129 | 1/20 | 0.54 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
| ▸ | AKT2 | P31751 | 1/20 | 0.54 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.54 |
| ▸ | PRKCI | P41743 | 1/20 | 0.54 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.54 |
| ▸ | MST1R | Q04912 | 1/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.54 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.54 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24862397 | 0.92 | ROCK2 (0.70) | ROCK2ROCK1PLK4PRKD3CHEK2 | |
| SCHEMBL15639004 | 0.92 | ROCK2 (0.74) | ROCK2ROCK1PRKCQ | |
| SCHEMBL15639461 | 0.84 | ROCK2 (0.77) | ROCK2ROCK1 | |
| SCHEMBL15639826 | 0.83 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL17041146 | 0.82 | ROCK2 (0.75) | ROCK2ROCK1 | |
| SCHEMBL17041171 | 0.82 | ROCK2 (0.74) | ROCK2ROCK1 | |
| SCHEMBL15639136 | 0.81 | KDR (0.73) | ROCK2ROCK1 | |
| SCHEMBL17040602 | 0.81 | ROCK2 (0.80) | ROCK2ROCK1 | |
| SCHEMBL15639264 | 0.81 | ROCK2 (0.74) | ROCK2ROCK1 | |
| SCHEMBL32670264 | 0.81 | ROCK2 (0.74) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015157556-A1 | TREATMENT OF GVHD | KADMON CORPORATION, LLC (US) | 2015-10-15 | — | — | WO | disclosed |