Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 8/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.61 |
| ▸ | RAB9A | P51151 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.61 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | APOBEC3A | P31941 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13856607 | 0.76 | POLB (1.00) | MEN1KMT2AKDM4EHSD17B10RXFP1 | |
| SCHEMBL1011158 | 0.76 | TDP1 (0.63) | MEN1KMT2AKDM4EHSD17B10RXFP1 | |
| SCHEMBL1061821 | 0.74 | RECQL (0.67) | MEN1KMT2AKDM4EHSD17B10RXFP1 | |
| SCHEMBL1718847 | 0.74 | POLB (0.79) | MEN1KMT2AKDM4EHSD17B10RXFP1 | |
| SCHEMBL1718574 | 0.72 | RECQL (0.74) | MEN1KMT2AKDM4EHSD17B10RXFP1 | |
| SCHEMBL15292427 | 0.69 | ALDH1A1 (0.97) | KMT2AKDM4EPOLBTDP1ALDH1A1 | |
| SCHEMBL1866973 | 0.69 | NPC1 (0.67) | MEN1KMT2AKDM4ERXFP1POLB | |
| SCHEMBL928041 | 0.68 | ALDH1A1 (1.00) | KMT2AKDM4EPOLBTDP1ALDH1A1 | |
| SCHEMBL15292429 | 0.68 | ALDH1A1 (1.00) | KMT2AKDM4EPOLBTDP1ALDH1A1 | |
| SCHEMBL1080204 | 0.68 | RECQL (0.59) | MEN1KMT2AKDM4EHSD17B10RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |