Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 7/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719497 | 0.90 | KMT2A (0.59) | KMT2AUSP2ALDH1A1KDM4EGAA | |
| SCHEMBL1717661 | 0.87 | ALDH1A1 (0.69) | KMT2AUSP2ALDH1A1KDM4EGAA | |
| SCHEMBL4210838 | 0.85 | HPGD (0.70) | USP2ALDH1A1KDM4EGAACASP1 | |
| SCHEMBL1718598 | 0.83 | USP2 (0.79) | USP2ALDH1A1KDM4EGAACASP1 | |
| SCHEMBL1718497 | 0.80 | ALDH1A1 (0.68) | KMT2AUSP2ALDH1A1KDM4EGAA | |
| SCHEMBL4206778 | 0.79 | ALDH1A1 (0.81) | KMT2AUSP2ALDH1A1KDM4EGAA | |
| SCHEMBL1718156 | 0.77 | HTT (0.71) | KMT2AALDH1A1KDM4EGAACASP1 | |
| SCHEMBL1718611 | 0.77 | KDM4E (0.70) | KMT2AALDH1A1KDM4EGAACASP1 | |
| SCHEMBL1718397 | 0.76 | USP2 (0.74) | KMT2AUSP2ALDH1A1KDM4EGAA | |
| SCHEMBL1718386 | 0.76 | KMT2A (0.67) | KMT2AUSP2ALDH1A1KDM4ECASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |