Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719078 | 0.93 | KDM4E (0.69) | MAPTTP53KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1718354 | 0.88 | KDM4E (0.56) | MAPTTP53KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1719054 | 0.87 | TTR (0.68) | MAPTTP53KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1718061 | 0.81 | TP53 (0.67) | MAPTTP53KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1719812 | 0.81 | KDM4E (0.57) | MAPTTP53KDM4EALDH1A1HPGD | |
| SCHEMBL1719145 | 0.81 | KDM4E (0.80) | MAPTTP53KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1718125 | 0.80 | MAPT (0.80) | MAPTTP53KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1718477 | 0.80 | KDM4E (0.64) | MAPTTP53KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1718481 | 0.80 | MAPT (0.70) | MAPTTP53KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1718319 | 0.80 | MAPT (0.70) | MAPTTP53KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |