Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | TP53 | P04637 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | TACR3 | P29371 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PHGDH | O43175 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1719078 | 0.86 | KDM4E (0.69) | KDM4EALDH1A1TP53MAPTHPGD | |
| SCHEMBL1718028 | 0.85 | KDM4E (0.66) | KDM4EALDH1A1TP53MAPTHTT | |
| SCHEMBL1718283 | 0.80 | MAPT (0.62) | KDM4EALDH1A1TP53MAPTHPGD | |
| SCHEMBL4207359 | 0.80 | TP53 (0.84) | KDM4EALDH1A1TP53MAPTHTT | |
| SCHEMBL14014123 | 0.79 | KDM4E (0.79) | KDM4EALDH1A1TP53MAPTHTT | |
| SCHEMBL4491712 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1TP53MAPTHTT | |
| SCHEMBL25970341 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1TP53MAPTHTT | |
| Hydrochloric Acid SCHEMBL30516216 | 0.78 | KDM4E (0.58) | KDM4EALDH1A1TP53MAPTHTT | |
| SCHEMBL1718354 | 0.77 | KDM4E (0.56) | KDM4EALDH1A1TP53MAPTHPGD | |
| SCHEMBL1718891 | 0.77 | KDM4E (0.67) | KDM4EALDH1A1TP53MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |