Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | CASP1 | P29466 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718188 | 0.94 | ALDH1A1 (0.78) | ALDH1A1NPSR1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL1718222 | 0.91 | KDM4E (0.68) | ALDH1A1NPSR1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL1718257 | 0.87 | KDM4E (0.60) | ALDH1A1NPSR1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL1720214 | 0.84 | KDM4E (0.72) | ALDH1A1NPSR1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL16615203 | 0.82 | KDM4E (0.67) | ALDH1A1NPSR1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL1718860 | 0.82 | ALDH1A1 (0.82) | ALDH1A1NPSR1KMT2AL3MBTL1KDM4E | |
| SCHEMBL14367441 | 0.82 | KDM4E (0.76) | ALDH1A1NPSR1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL6030712 | 0.81 | KDM4E (0.80) | ALDH1A1KMT2ASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL1719255 | 0.81 | ALDH1A1 (0.57) | ALDH1A1NPSR1KMT2AL3MBTL1SMN1; SMN2 | |
| SCHEMBL1718970 | 0.81 | ALDH1A1 (0.66) | ALDH1A1NPSR1KMT2AL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |