Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.58 |
| ▸ | KDR | P35968 | 19/20 | 0.58 |
| ▸ | MST1R | Q04912 | 2/20 | 0.58 |
| ▸ | AXL | P30530 | 2/20 | 0.58 |
| ▸ | FLT3 | P36888 | 2/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | HCK | P08631 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | BCR | P11274 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | ABL2 | P42684 | 1/20 | 0.58 |
| ▸ | FRK | P42685 | 1/20 | 0.58 |
| ▸ | SYK | P43405 | 1/20 | 0.58 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.58 |
| ▸ | MERTK | Q12866 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL106729 | 0.90 | MET (0.73) | METKDRMST1RAXLFLT3 | |
| SCHEMBL13927705 | 0.85 | MET (0.79) | METKDRMST1RAXLFLT3 | |
| SCHEMBL2533066 | 0.84 | MET (0.73) | METKDRMST1RAXLFLT3 | |
| SCHEMBL169907 | 0.83 | KDR (0.58) | METKDRMST1RAXLFLT3 | |
| SCHEMBL2121003 | 0.81 | MET (0.78) | METKDRMST1RAXLFLT3 | |
| SCHEMBL13926131 | 0.81 | MET (0.72) | METKDRMST1RAXLFLT3 | |
| SCHEMBL12557605 | 0.80 | MST1R (0.49) | METKDRMST1RAXLFLT3 | |
| SCHEMBL13927474 | 0.79 | MET (0.56) | METKDRMST1RAXLFLT3 | |
| SCHEMBL13926138 | 0.77 | MET (0.60) | METKDRMST1RAXLFLT3 | |
| SCHEMBL169838 | 0.77 | MET (0.72) | METKDRMST1RAXLFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426108-A1 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | MethylGene Inc. (CA) | 2012-03-07 | — | — | EP | disclosed |