Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718667 | 0.94 | MAPT (0.67) | MAPK1USP2MAPTRXFP1GAA | |
| SCHEMBL1718638 | 0.90 | MAPK1 (0.66) | MAPK1USP2MAPTRXFP1GAA | |
| SCHEMBL1718437 | 0.89 | RXFP1 (0.73) | MAPK1MAPTRXFP1GAAL3MBTL1 | |
| SCHEMBL1718280 | 0.88 | MAPK1 (0.68) | MAPK1USP2MAPTRXFP1GAA | |
| SCHEMBL1718005 | 0.86 | MAPK1 (0.63) | MAPK1USP2MAPTRXFP1GAA | |
| SCHEMBL1718636 | 0.85 | MAPK1 (0.62) | MAPK1USP2MAPTRXFP1GAA | |
| SCHEMBL1719141 | 0.84 | MAPT (0.64) | MAPK1USP2MAPTRXFP1GAA | |
| SCHEMBL1718992 | 0.83 | USP2 (0.69) | MAPK1USP2MAPTRXFP1GAA | |
| SCHEMBL1718513 | 0.82 | MAPT (0.64) | MAPK1USP2MAPTRXFP1GAA | |
| SCHEMBL3278674 | 0.82 | USP2 (0.70) | MAPK1USP2MAPTRXFP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |