Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.75 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718651 | 0.90 | RXFP1 (0.78) | RXFP1MAPTALDH1A1POLBMAPK1 | |
| SCHEMBL1719027 | 0.89 | RXFP1 (0.80) | RXFP1MAPTALDH1A1POLBKDM4E | |
| SCHEMBL1718280 | 0.89 | MAPK1 (0.68) | RXFP1MAPTALDH1A1POLBKDM4E | |
| SCHEMBL1718437 | 0.88 | RXFP1 (0.73) | RXFP1MAPTALDH1A1POLBMAPK1 | |
| SCHEMBL1718964 | 0.86 | RXFP1 (1.00) | RXFP1MAPTALDH1A1POLBKDM4E | |
| SCHEMBL1718558 | 0.85 | RXFP1 (0.76) | RXFP1MAPTALDH1A1POLBKDM4E | |
| SCHEMBL1719711 | 0.85 | POLB (0.70) | RXFP1MAPTALDH1A1POLBMAPK1 | |
| SCHEMBL1717917 | 0.85 | RXFP1 (0.72) | RXFP1MAPTALDH1A1POLBKDM4E | |
| SCHEMBL1719430 | 0.83 | RXFP1 (0.72) | RXFP1MAPTALDH1A1POLBKDM4E | |
| SCHEMBL1719773 | 0.82 | RXFP1 (0.71) | RXFP1MAPTALDH1A1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |