Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 1.00 |
| ▸ | HTT | P42858 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 7/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 4/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4201226 | 0.99 | KDM4E (0.98) | KDM4EHTTALDH1A1MAPTMAPK1 | |
| SCHEMBL25430390 | 0.98 | KDM4E (0.96) | KDM4EHTTALDH1A1MAPTMAPK1 | |
| SCHEMBL25969033 | 0.89 | KDM4E (0.80) | KDM4EHTTALDH1A1MAPTMAPK1 | |
| SCHEMBL4737182 | 0.88 | KDM4E (0.78) | KDM4EHTTALDH1A1MAPTMAPK1 | |
| SCHEMBL25970230 | 0.88 | KDM4E (0.78) | KDM4EHTTALDH1A1MAPTMAPK1 | |
| SCHEMBL4215699 | 0.87 | KDM4E (0.77) | KDM4EHTTALDH1A1MAPTMAPK1 | |
| SCHEMBL25969141 | 0.87 | KDM4E (0.77) | KDM4EHTTALDH1A1MAPTMAPK1 | |
| SCHEMBL14366824 | 0.86 | KDM4E (0.76) | KDM4EHTTALDH1A1MAPTMAPK1 | |
| SCHEMBL25338396 | 0.85 | KDM4E (0.74) | KDM4EHTTALDH1A1MAPTMAPK1 | |
| SCHEMBL25335602 | 0.85 | KDM4E (0.74) | KDM4EHTTALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |