Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12676283 | 0.85 | OGG1 (0.46) | SLC6A4CYP2D6SLC6A2SLC6A3MAPT | |
| SCHEMBL13454235 | 0.82 | MAPT (0.33) | SLC6A2MAPT | |
| SCHEMBL12676324 | 0.81 | SLC6A2 (0.33) | SLC6A4SLC6A2SLC6A3FFAR4MAPT | |
| SCHEMBL12676303 | 0.77 | FFAR4 (0.36) | FFAR4 | |
| SCHEMBL12676325 | 0.77 | FFAR4 (0.36) | FFAR4 | |
| SCHEMBL12676302 | 0.77 | FFAR4 (0.36) | FFAR4 | |
| SCHEMBL30724172 | 0.74 | SYK (0.34) | FFAR4 | |
| SCHEMBL13454199 | 0.73 | FFAR4 (0.34) | FFAR4 | |
| SCHEMBL18625771 | 0.73 | FFAR4 (0.34) | FFAR4MAPT | |
| SCHEMBL13454178 | 0.73 | FFAR4 (0.34) | FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9162968-B2 | Cyclohexane-1,3-diones for use in the treatment of amyotrophic lateral sclerosis | NORTHWESTERN UNIVERSITY (US) | 2015-10-20 | — | — | US | disclosed |
| US-9162968-B2 | Cyclohexane-1,3-diones for use in the treatment of amyotrophic lateral sclerosis | NORTHWESTERN UNIVERSITY (US) | 2015-10-20 | — | — | US | disclosed |