⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL375923 | 0.74 | — | — | |
| SCHEMBL4281008 | 0.72 | — | — | |
| SCHEMBL7671653 | 0.70 | — | — | |
| Formaldehyde SCHEMBL6260184 | 0.70 | — | — | |
| SCHEMBL22559959 | 0.70 | — | — | |
| SCHEMBL7751136 | 0.70 | — | — | |
| SCHEMBL3548899 | 0.70 | CAD (0.47) | — | |
| SCHEMBL13439697 | 0.70 | CAD (0.47) | — | |
| SCHEMBL29953785 | 0.70 | CAD (0.47) | — | |
| SCHEMBL8525696 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11214801-B2 | RNAi agents and compositions for inhibiting expression of apolipoprotein C-III (APOC3) | Arrowhead Pharmaceuticals, Inc. (US) | 2022-01-04 | — | — | US | disclosed |
| US-20200299690-A1 | RNAi Agents And Compositions for Inhibiting Expression of Apolipoprotein C-III (APOC3) | SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT | 2020-09-24 | — | — | US | disclosed |
| US-10597657-B2 | RNAi agents and compositions for inhibiting expression of apolipoprotein C-III (APOC3) | Arrowhead Pharmaceuticals, Inc. (US) | 2020-03-24 | — | — | US | disclosed |
| US-20190078088-A1 | RNAi Agents And Compositions for Inhibiting Expression of Apolipoprotein C-III (APOC3) | SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT | 2019-03-14 | — | — | US | disclosed |
| EP-2416781-B1 | COMBINATION OF CYTIDINE-BASED ANTINEOPLASTIC DRUGS WITH CYTIDINE DEAMINASE INHIBITOR AND USE THEREOF IN THE TREATMENT OF CANCER | OTSUKA PHARMA CO LTD (JP) | 2017-03-08 | — | — | EP | disclosed |
| EP-2207786-B1 | 2'-FLUORO-2'-DEOXYTETRAHYDROURIDINES AS CYTIDINE DEAMINASE INHIBITORS | EISAI INC (US) | 2012-03-07 | — | — | EP | disclosed |
| EP-0269102-B1 | ACID-PROTONATED WATER-DILUTABLE BINDERS | BASF Lacke + Farben AG (DE) | 1991-03-06 | — | — | EP | disclosed |
| EP-0165556-B1 | HEAT-CURABLE COATING AGENT, ITS USE OR A PROCESS FOR PREPARING THE SAME | BASF Aktiengesellschaft (DE) | 1989-09-13 | — | — | EP | disclosed |
| EP-0165558-B1 | COATING AGENT, ITS MANUFACTURE AND USE THEREOF | BASF Aktiengesellschaft (DE) | 1989-08-30 | — | — | EP | disclosed |
| EP-0269102-A2 | Acid-protonated water-dilutable binders | BASF Lacke + Farben AG (DE) | 1988-06-01 | — | — | EP | disclosed |
| EP-0165558-A2 | Coating agent, its manufacture and use thereof | BASF Aktiengesellschaft (DE) | 1985-12-27 | — | — | EP | disclosed |
| EP-0165556-A2 | Heat-curable coating agent, its use or a process for preparing the same | BASF Aktiengesellschaft (DE) | 1985-12-27 | — | — | EP | disclosed |
| EP-0014456-B1 | HEXAHYDROPYRIMIDIN-(4)-YL-ETHERS AND PROCESS FOR THEIR PREPARATION | BASF Aktiengesellschaft (DE) | 1982-06-23 | — | — | EP | disclosed |
| EP-0005162-B1 | PROCESS FOR PREPARING 5,5-DISUBSTITUTED 4-CARBAMIDO-HEXAHYDROPYRIMIDINES | BASF Aktiengesellschaft (DE) | 1981-12-30 | — | — | EP | disclosed |
| US-4262121-A | STARTING MATERIALS FOR PREPARATION OF DYES AND PESTICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1981-04-14 | — | — | US | disclosed |
| EP-0014456-A1 | Hexahydropyrimidin-(4)-yl-ethers and process for their preparation | BASF Aktiengesellschaft (DE) | 1980-08-20 | — | — | EP | disclosed |
| EP-0008345-A1 | Hexahydropyrimidyl-4 ethers and process for their preparation | BASF Aktiengesellschaft (DE) | 1980-03-05 | — | — | EP | disclosed |
| EP-0005504-A1 | Process for the preparation of 5,5-disubstituted-4-ureido-hexahydropyrimidines | BASF Aktiengesellschaft (DE) | 1979-11-28 | — | — | EP | disclosed |
| EP-0005162-A1 | Process for preparing 5,5-disubstituted 4-carbamido-hexahydropyrimidines | BASF Aktiengesellschaft (DE) | 1979-11-14 | — | — | EP | disclosed |
| EP-0004608-A1 | 4-Acylamido-hexahydropyrimidines, and process for their preparation | BASF Aktiengesellschaft (DE) | 1979-10-17 | — | — | EP | disclosed |