Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.72 |
| ▸ | MAPT | P10636 | 8/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.72 |
| ▸ | CASP1 | P29466 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | HPGD | P15428 | 7/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 4/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CASP7 | P55210 | 2/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718995 | 0.89 | KDM4E (0.78) | KDM4EMAPTHSD17B10CASP1RAB9A | |
| SCHEMBL1718852 | 0.87 | KDM4E (0.78) | KDM4EMAPTHSD17B10CASP1RAB9A | |
| SCHEMBL1718421 | 0.86 | ALDH1A1 (0.66) | KDM4EMAPTHSD17B10CASP1RAB9A | |
| SCHEMBL1719581 | 0.83 | MAPT (0.72) | KDM4EMAPTHSD17B10CASP1ALDH1A1 | |
| SCHEMBL1718600 | 0.82 | KDM4E (0.73) | KDM4EMAPTHSD17B10CASP1RAB9A | |
| SCHEMBL1719545 | 0.81 | KDM4E (0.71) | KDM4EMAPTHSD17B10CASP1RAB9A | |
| SCHEMBL1720090 | 0.80 | KDM4E (0.85) | KDM4EMAPTHSD17B10CASP1RAB9A | |
| SCHEMBL1718041 | 0.79 | KDM4E (0.83) | KDM4EMAPTHSD17B10CASP1RAB9A | |
| SCHEMBL1718245 | 0.79 | KDM4E (0.83) | KDM4EMAPTHSD17B10CASP1RAB9A | |
| SCHEMBL1720013 | 0.79 | MAPT (0.76) | KDM4EMAPTHSD17B10CASP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |