Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | MIF | P14174 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17189694 | 0.86 | HDAC3 (0.41) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL19443774 | 0.82 | HDAC3 (0.37) | ACHEHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL16273133 | 0.82 | ACHE (0.44) | ACHECYP1A2CYP2A6TSHRMIF | |
| SCHEMBL19452774 | 0.82 | MIF (0.36) | CYP1A2MAPTMIFALDH1A1 | |
| SCHEMBL29444850 | 0.82 | MIF (0.38) | ACHECYP1A2MAPTMIFALDH1A1 | |
| SCHEMBL17181375 | 0.82 | MIF (0.38) | ACHECYP1A2MAPTMIFALDH1A1 | |
| SCHEMBL19443915 | 0.78 | MIF (0.35) | MAPTTSHRMIFCYP3A4HPGD | |
| SCHEMBL19452739 | 0.78 | MIF (0.30) | MIF | |
| SCHEMBL17189696 | 0.77 | HDAC3 (0.39) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL20403614 | 0.76 | TP53 (0.41) | TP53MAPTALDH1A1TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9512102-B2 | 4,6-difluorodibenzothiophene derivatives | MERCK PATENT GMBH (DE) | 2016-12-06 | — | — | US | disclosed |
| US-20150299161-A1 | 4,6-DIFLUORODIBENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299161-A1 | 4,6-DIFLUORODIBENZOTHIOPHENE DERIVATIVES | DDT, CD2, CYP4F2 | ACHE 3644/4885HDAC3 4739/4885HDAC4 3885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.