Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 7/20 | 0.46 |
| ▸ | CASP1 | P29466 | 3/20 | 0.46 |
| ▸ | CASP7 | P55210 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4211110 | 0.90 | KMT2A (0.77) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL1717794 | 0.87 | KMT2A (0.68) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL1718334 | 0.87 | KMT2A (1.00) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL1718393 | 0.83 | KMT2A (0.67) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL1719114 | 0.82 | KMT2A (0.66) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL1719319 | 0.82 | KDM4E (0.70) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL1719435 | 0.81 | KMT2A (0.60) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL4217010 | 0.81 | ALDH1A1 (0.66) | KMT2AMEN1ALDH1A1KDM4EMAPT | |
| SCHEMBL1718403 | 0.81 | KMT2A (0.63) | KMT2AMEN1ALDH1A1KDM4ELMNA | |
| SCHEMBL1718528 | 0.80 | KMT2A (0.63) | KMT2AMEN1ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |