⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17696 | 0.74 | SCN9A (0.36) | — | |
| SCHEMBL17108 | 0.71 | HTR2C (0.32) | — | |
| SCHEMBL16349 | 0.67 | GCK (0.38) | — | |
| SCHEMBL17033 | 0.67 | GCK (0.46) | — | |
| SCHEMBL12089870 | 0.59 | HCRTR1 (0.31) | — | |
| SCHEMBL17282 | 0.58 | HTR2A (0.30) | — | |
| SCHEMBL8718984 | 0.57 | MAPK1 (0.35) | — | |
| SCHEMBL9413133 | 0.56 | KDM4E (0.42) | — | |
| SCHEMBL8715080 | 0.53 | CYP3A4 (0.34) | — | |
| SCHEMBL8719165 | 0.51 | MAPK1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |