Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17222 | 0.77 | GCK (0.47) | — | |
| SCHEMBL16561 | 0.77 | GCK (0.38) | RORC | |
| SCHEMBL17195 | 0.74 | — | — | |
| SCHEMBL17434 | 0.73 | GCK (0.31) | — | |
| SCHEMBL12077402 | 0.72 | SCN9A (0.32) | SCN9ARORC | |
| Trifluoroacetic Acid SCHEMBL12079777 | 0.69 | SCN9A (0.32) | SCN9A | |
| SCHEMBL12090188 | 0.60 | HCRTR1 (0.33) | SCN9A | |
| SCHEMBL12079779 | 0.59 | SCN9A (0.33) | SCN9AEPHX2 | |
| SCHEMBL22679235 | 0.58 | EPHX2 (0.33) | SCN9AEPHX2 | |
| SCHEMBL17413 | 0.54 | ROCK2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |