Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | TTR | P02766 | 1/20 | 0.58 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | CASP1 | P29466 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzylamine SCHEMBL1719112 | 0.86 | KDM4E (0.67) | KDM4EHSD17B10ALDH1A1SMN1; SMN2TTR | |
| Benzylamine SCHEMBL1719060 | 0.86 | KDM4E (0.63) | KDM4EHSD17B10ALDH1A1SMN1; SMN2TTR | |
| SCHEMBL3278525 | 0.85 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1SMN1; SMN2TTR | |
| SCHEMBL1718629 | 0.83 | HPGD (0.68) | KDM4EHSD17B10ALDH1A1SMN1; SMN2HPGD | |
| Benzylamine SCHEMBL1718987 | 0.83 | MAPT (0.82) | KDM4EHSD17B10ALDH1A1SMN1; SMN2TTR | |
| SCHEMBL1719920 | 0.81 | KDM4E (0.66) | KDM4EHSD17B10ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL3284626 | 0.78 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1SMN1; SMN2TTR | |
| SCHEMBL14478857 | 0.78 | TP53 (0.86) | KDM4EHSD17B10ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1719145 | 0.77 | KDM4E (0.80) | KDM4EHSD17B10ALDH1A1SMN1; SMN2TTR | |
| SCHEMBL6030712 | 0.77 | KDM4E (0.80) | KDM4EHSD17B10ALDH1A1SMN1; SMN2TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |