Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 8/20 | 0.42 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655534 | 0.90 | PI4KB (0.57) | PI4KBKDM4EFAAHLIMK2KCNH2 | |
| SCHEMBL655138 | 0.85 | LTA4H (0.42) | KCNH2MAPT | |
| SCHEMBL1694426 | 0.81 | PI4KB (0.47) | PI4KBKDM4EFAAHLIMK2SMN1; SMN2 | |
| SCHEMBL654888 | 0.75 | PI4KB (0.62) | PI4KBFAAHLIMK2KCNH2SMN1; SMN2 | |
| SCHEMBL654034 | 0.73 | DRD4 (0.43) | PI4KBKDM4EKCNH2SMN1; SMN2MAPT | |
| SCHEMBL654035 | 0.73 | MEN1 (0.44) | PI4KBSMN1; SMN2 | |
| SCHEMBL654810 | 0.72 | PI4KB (0.57) | PI4KBKCNH2MAPTRAB9A | |
| SCHEMBL652076 | 0.71 | PI4KB (0.63) | PI4KBFAAHLIMK2KCNH2SMN1; SMN2 | |
| SCHEMBL4528644 | 0.71 | PI4KB (0.62) | PI4KBFAAHLIMK2KCNH2MAPT | |
| SCHEMBL655003 | 0.70 | PI4KB (0.66) | PI4KBFAAHLIMK2KCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |