SCHEMBL17200529

SCHEMBL17200529

CS(=O)(=O)c1cc(N)c(O)c(Br)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 8/20 0.42
CA2 P00918 8/20 0.42
CA9 Q16790 7/20 0.42
CA12 O43570 3/20 0.42
CA4 P22748 1/20 0.42
CA6 P23280 1/20 0.42
CA5A P35218 1/20 0.42
CA7 P43166 1/20 0.42
CA14 Q9ULX7 1/20 0.42
CA5B Q9Y2D0 1/20 0.42
CA3 P07451 1/20 0.42
G6PD P11413 1/20 0.39
IDE P14735 1/20 0.39
ENPP2 Q13822 1/20 0.39
GAA P10253 3/20 0.38
MAPT P10636 2/20 0.38
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
PKM P14618 1/20 0.37
RAB9A P51151 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16650007 0.87 CYP3A4 (0.46) CA1CA2CA9CA4CA6
SCHEMBL21487375 0.83 CA2 (0.61) CA1CA2CA9CA12CA4
SCHEMBL17200426 0.81 GAA (0.41) CA1CA2CA9CA12CA4
SCHEMBL17208681 0.79 CA1 (0.39) CA1CA2CA9CA12CA4
SCHEMBL17200503 0.79 MAPT (0.42) CA1CA2CA9CA12CA4
SCHEMBL9350559 0.79 CA2 (0.67) CA1CA2CA9CA12CA4
SCHEMBL20917372 0.78 CA1 (0.43) CA1CA2CA9ENPP2WDR5
SCHEMBL17213570 0.78 GAA (0.54) CA1CA2CA9CA12G6PD
SCHEMBL11824069 0.78 CA12 (0.41) CA1CA2CA9CA12G6PD
SCHEMBL10710003 0.76 AKR1C4 (0.56) CA1CA2CA9CA12CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260092065-A1 CRYSTALLINE SOLID FORMS OF A BET INHIBITOR INCYTE CORP (US) 2026-04-02 US disclosed
US-12459943-B2 Crystalline solid forms of a BET inhibitor INCYTE CORPORATION (US) 2025-11-04 US disclosed
US-20250145621-A1 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS INCYTE HOLDINGS CORPORATION 2025-05-08 US disclosed
US-12227502-B2 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c] pyridin-7(6H)-ones as inhibitors of BET proteins INCYTE CORPORATION (US) 2025-02-18 US disclosed
US-20240309001-A1 CRYSTALLINE SOLID FORMS OF A BET INHIBITOR INCYTE CORPORATION 2024-09-19 US disclosed
US-12030882-B2 Crystalline solid forms of a bet inhibitor INCYTE CORPORATION (US) 2024-07-09 US disclosed
US-20240002381-A1 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS INCYTE CORPORATION 2024-01-04 US disclosed
EP-4234554-A2 CRYSTALLINE SOLID FORMS OF A BET INHIBITOR Incyte Corporation (US) 2023-08-30 EP disclosed
EP-4234554-A2 CRYSTALLINE SOLID FORMS OF A BET INHIBITOR Incyte Corporation (US) 2023-08-30 EP disclosed
EP-4218766-A1 1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS Incyte Holdings Corporation (US) 2023-08-02 EP disclosed
EP-3134403-A1 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS Incyte Corporation (US) 2017-03-01 EP disclosed
CN-106414442-A 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS 因赛特公司 2017-02-15 CN disclosed
US-9540368-B2 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins INCYTE CORPORATION (US) 2017-01-10 US disclosed
US-9540368-B2 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins INCYTE CORPORATION (US) 2017-01-10 US disclosed
US-9540368-B2 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins INCYTE CORPORATION (US) 2017-01-10 US disclosed
US-20150307493-A1 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS INCYTE CORPORATION (US) 2015-10-29 US disclosed
US-20150307493-A1 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS INCYTE CORPORATION (US) 2015-10-29 US disclosed
WO-2015164480-A1 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS INCYTE CORPORATION (US) 2015-10-29 WO disclosed
US-20150307493-A1 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS INCYTE CORPORATION (US) 2015-10-29 US disclosed
WO-2015164480-A1 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS INCYTE CORPORATION (US) 2015-10-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12030882-B2 Crystalline solid forms of a bet inhibitor BRD1, BRD3, BRD2 CA1 3670/4885CA2 4071/4885CA9 3374/4885
US-12459943-B2 Crystalline solid forms of a BET inhibitor BRD1, BRD3, BRD2 CA1 3670/4885CA2 4071/4885CA9 3374/4885
US-20240002381-A1 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS BRD3, BRD1, BRD2 CA1 4874/4885CA2 4825/4885CA9 4758/4885
US-20250145621-A1 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS BRD3, BRD1, BRD2 CA1 4874/4885CA2 4825/4885CA9 4758/4885
US-20150307493-A1 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS BRD3, BRD1, BRD2 CA1 4874/4885CA2 4825/4885CA9 4758/4885
US-20260092065-A1 CRYSTALLINE SOLID FORMS OF A BET INHIBITOR BRD2, BRDT, BRD1 CA1 4052/4885CA2 4427/4885CA9 3616/4885
US-20240309001-A1 CRYSTALLINE SOLID FORMS OF A BET INHIBITOR BRD1, BRD3, BRD2 CA1 3670/4885CA2 4071/4885CA9 3374/4885
US-12227502-B2 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c] pyridin-7(6H)-ones as inhibitors of BET proteins BRD3, BRD1, BRD2 CA1 4874/4885CA2 4825/4885CA9 4758/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.