Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.55 |
| ▸ | GAA | P10253 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720081 | 1.00 | MAPT (0.55) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL10198704 | 0.84 | L3MBTL1 (0.56) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL426317 | 0.84 | L3MBTL1 (0.56) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL13758963 | 0.84 | MAPT (0.53) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL426316 | 0.84 | L3MBTL1 (0.56) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL14530462 | 0.83 | MAPT (0.52) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL427380 | 0.83 | MAPT (0.53) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL427379 | 0.83 | MAPT (0.53) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL10073895 | 0.83 | MAPT (0.53) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL20024421 | 0.83 | MAPT (0.51) | MAPTGAAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458687-B1 | PYRIMIDINE COMPOUNDS AS INTERLEUKIN-12 (IL-12) INHIBITORS | SYNTA PHARMACEUTICALS CORP (US) | 2012-01-11 | — | — | EP | claimed |