Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655262 | 0.94 | PI4KB (0.75) | PI4KBKCNH2CYP3A4POLBLMNA | |
| SCHEMBL656634 | 0.88 | PI4KB (0.70) | PI4KBKCNH2CYP3A4POLBLMNA | |
| SCHEMBL654739 | 0.85 | PI4KB (0.83) | PI4KBKCNH2CYP3A4POLBLMNA | |
| SCHEMBL656541 | 0.84 | PI4KB (0.81) | PI4KBKCNH2CYP3A4POLBLMNA | |
| SCHEMBL654589 | 0.84 | PI4KB (0.65) | PI4KBKCNH2POLBLMNAMAPK1 | |
| SCHEMBL17102776 | 0.84 | PI4KB (0.63) | PI4KBKCNH2CYP3A4POLBLMNA | |
| SCHEMBL653182 | 0.81 | PI4KB (0.82) | PI4KBKCNH2CYP3A4POLBLMNA | |
| SCHEMBL654457 | 0.81 | PI4KB (0.77) | PI4KBKCNH2CYP3A4POLBLMNA | |
| SCHEMBL653167 | 0.81 | PI4KB (0.75) | PI4KBKCNH2CYP3A4POLBLMNA | |
| SCHEMBL654471 | 0.81 | PI4KB (0.75) | PI4KBKCNH2CYP3A4POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |