Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBTD1 | Q05BQ5 | 3/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.36 |
| ▸ | ABL1 | P00519 | 5/20 | 0.36 |
| ▸ | MAPK7 | Q13164 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1720233 | 0.84 | MCHR1 (0.39) | MBTD1L3MBTL3L3MBTL1HTR2BTP53 | |
| SCHEMBL1719055 | 0.75 | CYP2D6 (0.40) | L3MBTL3L3MBTL1MAPK7 | |
| SCHEMBL1719839 | 0.75 | EPHX2 (0.42) | MBTD1L3MBTL3L3MBTL1HTR2BTP53 | |
| SCHEMBL1719458 | 0.74 | L3MBTL3 (0.39) | MBTD1L3MBTL3L3MBTL1HTR2BPIK3CD | |
| SCHEMBL1719474 | 0.74 | HRH3 (0.41) | MBTD1L3MBTL3L3MBTL1 | |
| SCHEMBL1719834 | 0.71 | MAP3K7 (0.38) | MAPK7 | |
| SCHEMBL1719253 | 0.71 | MAP3K7 (0.38) | MAPK7 | |
| SCHEMBL1720468 | 0.71 | MAP3K7 (0.38) | MAPK7 | |
| SCHEMBL1719716 | 0.70 | EPHX2 (0.37) | HTR2BPIK3CDEPHX2ABL1MAPK7 | |
| SCHEMBL1719718 | 0.70 | EPHX2 (0.37) | HTR2BPIK3CDEPHX2ABL1MAPK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173735-B1 | IMIDAZOLE DERIVATIVES AS CCR2 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2012-01-11 | — | — | EP | claimed |