Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17201653 | 0.86 | DRD1 (1.00) | DRD1 | |
| SCHEMBL16335994 | 0.84 | DRD1 (1.00) | DRD1 | |
| SCHEMBL22402233 | 0.83 | DRD1 (1.00) | DRD1 | |
| SCHEMBL22402232 | 0.81 | DRD1 (0.75) | DRD1 | |
| SCHEMBL16334917 | 0.80 | DRD1 (1.00) | DRD1 | |
| SCHEMBL16335409 | 0.80 | DRD1 (1.00) | DRD1 | |
| SCHEMBL30362261 | 0.80 | DRD1 (1.00) | DRD1 | |
| SCHEMBL16338569 | 0.80 | DRD1 (1.00) | DRD1 | |
| SCHEMBL15698790 | 0.77 | DRD1 (0.75) | DRD1 | |
| SCHEMBL17228698 | 0.77 | DRD1 (0.66) | DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9540352-B2 | Substituted 1,7-naphthyridines as dopamine D1 ligands | PFIZER INC. (US) | 2017-01-10 | — | — | US | claimed |
| US-20150307494-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2015-10-29 | — | — | US | claimed |
| US-9850232-B2 | Heteroaromatic compounds and their use as dopamine D1 ligands | PFIZER INC. (US) | 2017-12-26 | — | — | US | disclosed |
| US-9540352-B2 | Substituted 1,7-naphthyridines as dopamine D1 ligands | PFIZER INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-9540352-B2 | Substituted 1,7-naphthyridines as dopamine D1 ligands | PFIZER INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-9540352-B2 | Substituted 1,7-naphthyridines as dopamine D1 ligands | PFIZER INC. (US) | 2017-01-10 | — | — | US | disclosed |
| US-20160200711-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2016-07-14 | — | — | US | disclosed |
| WO-2015162516-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2015-10-29 | — | — | WO | disclosed |
| US-20150307494-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2015-10-29 | — | — | US | disclosed |
| US-20150307494-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2015-10-29 | — | — | US | disclosed |
| US-20150307494-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | PFIZER INC. (US) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200711-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | DRD2, DRD1, DRD4 | DRD1 2/4885 |
| US-20150307494-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | DRD2, DRD1, DRD4 | DRD1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.