Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.64 |
| ▸ | DRD4 | P21917 | 5/20 | 0.64 |
| ▸ | DRD3 | P35462 | 5/20 | 0.64 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12742602 | 0.90 | DRD2 (0.64) | DRD2DRD4DRD3PLA2G7MGLL | |
| Hydrochloric Acid SCHEMBL125248 | 0.89 | DRD2 (0.62) | DRD2DRD4DRD3PLA2G7MGLL | |
| SCHEMBL12742617 | 0.88 | DRD2 (0.66) | DRD2DRD4DRD3PLA2G7MGLL | |
| SCHEMBL12742556 | 0.87 | DRD2 (0.60) | DRD2DRD4DRD3PLA2G7MGLL | |
| Hydrochloric Acid SCHEMBL1448869 | 0.87 | DRD2 (0.65) | DRD2DRD4DRD3PLA2G7MGLL | |
| Hydrochloric Acid SCHEMBL122848 | 0.87 | DRD2 (0.59) | DRD2DRD4DRD3PLA2G7MGLL | |
| SCHEMBL124437 | 0.82 | DRD4 (0.70) | DRD2DRD4DRD3PLA2G7MGLL | |
| SCHEMBL172192 | 0.82 | DRD2 (0.58) | DRD2DRD4DRD3PLA2G7MGLL | |
| Hydrochloric Acid SCHEMBL121960 | 0.81 | DRD2 (0.57) | DRD2DRD4DRD3PLA2G7MGLL | |
| SCHEMBL171928 | 0.79 | DRD2 (0.49) | DRD2DRD4DRD3PLA2G7MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2201002-B1 | 5-HT7 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2009048765-A1 | 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2009-04-16 | — | — | WO | disclosed |