Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 19/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 17/20 | 0.61 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.61 |
| ▸ | PIK3C3 | Q8NEB9 | 5/20 | 0.48 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.48 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.48 |
| ▸ | PI4KA | P42356 | 1/20 | 0.48 |
| ▸ | PRKDC | P78527 | 1/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL17203127 | 1.00 | PIK3CG (0.61) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3C3 | |
| Sulfuric Acid SCHEMBL17202951 | 1.00 | PIK3CG (0.61) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3C3 | |
| Sulfuric Acid SCHEMBL17202949 | 1.00 | PIK3CG (0.61) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3C3 | |
| Sulfuric Acid SCHEMBL17203250 | 0.99 | PIK3CG (0.62) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3C3 | |
| SCHEMBL48534 | 0.97 | PIK3CG (0.64) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3C3 | |
| Phosphoric Acid SCHEMBL17203108 | 0.95 | PIK3CG (0.59) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3C3 | |
| SCHEMBL48826 | 0.87 | PIK3CD (0.51) | PIK3CGPIK3CDPIK3CAPIK3CBPI4KB | |
| SCHEMBL48709 | 0.87 | PIK3CD (0.51) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3C3 | |
| SCHEMBL48872 | 0.87 | PIK3CD (0.53) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3C3 | |
| SCHEMBL49251 | 0.86 | PIK3CD (0.52) | PIK3CGPIK3CDPIK3CAPIK3CBPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015162584-A1 | CRYSTALLINE FORMS OF THE SULFATE SALT OF N-[5-(3-IMIDAZOL-1-YL-4-METHANESULFONYL-PHENYL)-4-METHYL-THIAZOL-2-YL]-ACETAMIDE | NOVARTIS AG (CH) | 2015-10-29 | — | — | WO | disclosed |