SCHEMBL1720330

SCHEMBL1720330

O=C(c1ccc(F)cc1)c1ccccc1NC(Cc1ccc(OCCc2ccc3c(c2)[nH]c2ccccc23)cc1)C(=O)O

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PPARG P37231 20/20 0.70
PPARA Q07869 3/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1719556 0.96 PPARG (0.71) PPARGPPARA
SCHEMBL1720777 0.94 PPARG (0.69) PPARGPPARA
SCHEMBL1721007 0.91 PPARG (0.61) PPARGPPARA
SCHEMBL5065105 0.89 PPARG (0.61) PPARGPPARA
SCHEMBL1720154 0.88 PPARG (0.63) PPARGPPARA
SCHEMBL1720328 0.87 PPARG (0.64) PPARGPPARA
SCHEMBL29930321 0.87 PPARG (0.64) PPARGPPARA
SCHEMBL29930451 0.86 PPARG (0.63) PPARGPPARA
SCHEMBL28494551 0.86 PPARG (0.63) PPARGPPARA
SCHEMBL1719558 0.83 PPARG (0.70) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107868032-B Substituted phenylpropionic acid compound enantiomer, and preparation method, composition and application thereof 深圳微芯生物科技股份有限公司 2020-12-15 CN claimed
CN-112479977-B Substituted phenylpropionic acid compound enantiomer, and preparation method, composition and application thereof 深圳微芯生物科技股份有限公司 2022-07-19 CN disclosed
CN-112479977-A Substituted phenylpropionic acid compound enantiomer, and preparation method, composition and application thereof 深圳微芯生物科技股份有限公司 2021-03-12 CN disclosed
CN-107868032-B Substituted phenylpropionic acid compound enantiomer, and preparation method, composition and application thereof 深圳微芯生物科技股份有限公司 2020-12-15 CN disclosed
EP-1569904-B1 SUBSTITUTED ARYLALCANOIC ACID DERIVATIVES AS PPAR PAN AGONISTS WITH POTENT ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY SHENZHEN CHIPSCREEN BIOSCIENCES LTD (CN) 2012-01-11 EP disclosed
EP-1569904-A4 SUBSTITUTED ARYLALCANOIC ACID DERIVATIVES AS PPAR PAN AGONISTS WITH POTENT ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY SHENZHEN CHIPSCREEN BIOSCIENCE (CN) 2008-04-16 EP disclosed
US-20080051321-A1 Substituted arylalcanoic acid derivatives as ppar pan agonists with potent antihyperglycemic and antihyperlipidemic activity LU XIAN-PING 2008-02-28 US disclosed
US-7268157-B2 Substituted arylalcanoic acid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity SHENZHEN CHIPSCREEN BIOSCIENCES, LTD. (CN) 2007-09-11 US disclosed
EP-1569904-A1 SUBSTITUTED ARYLALCANOIC ACID DERIVATIVES AS PPAR PAN AGONISTS WITH POTENT ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY Shenzhen Chipscreen Biosciences Ltd. (CN) 2005-09-07 EP disclosed
US-20040142921-A1 Substituted arylalcanoic acid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) 2004-07-22 US disclosed
WO-2004048333-A1 SUBSTITUTED ARYLALCANOIC ACID DERIVATIVES AS PPAR PAN AGONISTS WITH POTENT ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (US) 2004-06-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040142921-A1 Substituted arylalcanoic acid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity GPR119, PPARG, PPARA PPARG 2/4885PPARA 3/4885
US-20080051321-A1 Substituted arylalcanoic acid derivatives as ppar pan agonists with potent antihyperglycemic and antihyperlipidemic activity GPR119, PPARG, PPARA PPARG 2/4885PPARA 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.