Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.41 |
| ▸ | HRH2 | P25021 | 3/20 | 0.40 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | YAP1 | P46937 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL865013 | 0.94 | GPR119 (0.44) | GPR119HRH2HRH1CHEK2DPP4 | |
| SCHEMBL1722091 | 0.93 | HRH2 (0.42) | GPR119HRH2HRH1CHEK2ALDH1A1 | |
| SCHEMBL864618 | 0.89 | DPP4 (0.40) | GPR119DPP4DPP8DPP9DPP7 | |
| SCHEMBL10101194 | 0.89 | DPP4 (0.40) | GPR119DPP4DPP8DPP9DPP7 | |
| SCHEMBL865462 | 0.89 | DPP4 (0.40) | GPR119DPP4DPP8DPP9DPP7 | |
| SCHEMBL864616 | 0.89 | DPP4 (0.40) | GPR119DPP4DPP8DPP9DPP7 | |
| SCHEMBL864617 | 0.89 | DPP4 (0.40) | GPR119DPP4DPP8DPP9DPP7 | |
| SCHEMBL865461 | 0.89 | DPP4 (0.40) | GPR119DPP4DPP8DPP9DPP7 | |
| SCHEMBL865460 | 0.89 | DPP4 (0.40) | GPR119DPP4DPP8DPP9DPP7 | |
| SCHEMBL865661 | 0.88 | GPR119 (0.42) | GPR119DPP4DPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406247-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | Prosidion Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103333-A1 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |