Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | JMJD6 | Q6NYC1 | 3/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17201348 | 0.89 | CHRM1 (0.44) | CHRM1KDM4EKMT2ACYP19A1KEAP1 | |
| SCHEMBL17201295 | 0.80 | CHRM1 (0.45) | CHRM1KDM4EKMT2ACYP19A1KEAP1 | |
| SCHEMBL28841115 | 0.78 | VDR (0.40) | KDM4ERAB9AKMT2AMEN1 | |
| SCHEMBL18725437 | 0.77 | CHRM1 (0.46) | CHRM1KDM4ERAB9ASMN1; SMN2KMT2A | |
| SCHEMBL28131930 | 0.76 | USP2 (0.42) | KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL28841022 | 0.76 | CHRM1 (0.44) | CHRM1KDM4EKMT2AMEN1 | |
| SCHEMBL17201004 | 0.75 | CHRM1 (0.47) | CHRM1KDM4EKMT2ACYP19A1KEAP1 | |
| SCHEMBL17201028 | 0.75 | BRD4 (0.39) | — | |
| SCHEMBL26966632 | 0.75 | CHRM1 (0.45) | CHRM1KDM4ERAB9ASMN1; SMN2KMT2A | |
| SCHEMBL17201221 | 0.74 | CHRM1 (0.42) | CHRM1KDM4EKMT2ACYP19A1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134386-A1 | ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR THE TREATMENT OF ALZHEIMERS DISEASE | Takeda Pharmaceutical Company Limited (JP) | 2017-03-01 | — | — | EP | disclosed |
| WO-2015163485-A1 | ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR THE TREATMENT OF ALZHEIMERS DISEASE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-10-29 | — | — | WO | disclosed |